Celebrex works, but it requires a pretty big daily dose to have any real effect on PA. 200mg 2X/day is maximum but that is usually what is needed. And at that dose, it is still not completely safe for the stomach. What is Celebrex? Celebrex (Celecoxib) belongs to the class of nonsteroidal anti-inflammatory drugs (NSAID) and it is used for the treatment of arthritis, dysmenhorea and colonic polyps besides being a popular analgesic (1, 2, 3). What other drugs will affect Celebrex? Ask your doctor before using Celebrex if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily. Celebrex is a non-generic prescription medication that is prescribed to people who suffer from arthritis and other acute pain issues. Also known as celecoxib, this prescription drug is used for pain management primarily in patients with rheumatoid arthritis (RA), osteoarthritis (OA), and ankylosing spondylitis. Celebrex is the brand name for the prescription pain reliever celecoxib, the drug's active ingredient. Doctors prescribe Celebrex to treat pain, swelling, and stiffness of arthritis and some other. General Dosing Instructions. Carefully consider the potential benefits and risks of CELEBREX and other treatment options before deciding to use CELEBREX. But many doctors are puzzled because the operation doesn't carry a 100 percent guarantee, it's major surgery -- and women have other options, from a once-a-day pill to careful monitoring. The FDA issued a warning on April 7, 2005, regarding cardiovascular risks (such as heart attack and stroke) associated with Celebrex and other NSAIDs. The FDA advised doctors to carefully weigh the potential benefits and risks of Celebrex and other treatment options before a decision is made to use Celebrex. Some alternatives to Celebrex include other medications (such as Tylenol or ibuprofen). Non-medication options include exercise, surgery, and alternative therapies (such as acupuncture or TENS). Talk to your healthcare provider about possible alternatives if this medication is not working for you.